Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Sov. Genet. (Engl. Transl.); (United States)

OSTI ID:5826660

Derzhavets, E M; Kim, A I; Aslanyan, M M

The spectrum and frequency of chromosomal aberrations in the somatic cells of III instar larvae of Drosophila melanogaster mutator line were studied using three of its derivatives (sbt, if, and w/sup a/) and line w as control. It has been demonstrated that the frequency of anaphases with bridges and acentric fragments increases in the neuroblast of flies of the mutator line as well as in the neuroblasts of the larvae of the lines sbt, if, and w/sup a/. The metaphase analysis revealed that the mutator line and its derivatives are characterized by higher frequencies of chromosomal aberrations as compared to the control. Chromatid breaks are predominant type of rearrangements. These results, suggest probably presence of the specific mutator factor or factors in the line studied, affecting chromosomal structure and, possibly, activating migration of the mobile genetic elements in the mutator line.

• Research Organization: M.V. Lomonosov Moscow State Univ. (USSR)
• OSTI ID: 5826660
• Journal Information: Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 24:5; ISSN SOGEB
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGY
CELL DIVISION
CHROMATIDS
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
CYTOLOGY
DIPTERA
DROSOPHILA
FLIES
FRUIT FLIES
GANGLIONS
GENE MUTATIONS
GENETIC EFFECTS
GENETICS
INSECTS
INSTABILITY
INVERTEBRATES
LARVAE
MITOSIS
MORPHOLOGICAL CHANGES
MUTANTS
MUTATION FREQUENCY
MUTATIONS
NERVE CELLS
NERVOUS SYSTEM
REVERTANTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
SPONTANEOUS MUTATIONS
STRUCTURAL CHEMICAL ANALYSIS