Spontaneous genomic instability in humans: Final report
Technical Report
·
OSTI ID:5822852
The primary goal of this research was to determine if DNA techniques could be used to investigate spontaneous and radiation induced germinal mutation rates in man. The usual approach is to examine a large number of loci with low mutations rates, in a large numbers of individuals. The Japanese atomic bomb survivor studies have not shown significantly increased germinal mutation rates in those individuals exposed to radiation. This may be due to relative radiation resistance, low levels of radiation in most subjects, or to the insensitivity of the techniques. An alternative approach is the examination in a small number of individuals of a small number of loci each of which show very high germinal mutation rates. We have demonstrated the practical feasibility of this approach.
- Research Organization:
- City of Hope National Medical Center, Duarte, CA (USA)
- DOE Contract Number:
- FG03-85ER60305
- OSTI ID:
- 5822852
- Report Number(s):
- DOE/ER/60305-T1; ON: DE89015548
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
A-BOMB SURVIVORS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DETECTION
DNA
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETICALLY SIGNIFICANT DOSE
HUMAN POPULATIONS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PROGRESS REPORT
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
59 BASIC BIOLOGICAL SCIENCES
A-BOMB SURVIVORS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DETECTION
DNA
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETICALLY SIGNIFICANT DOSE
HUMAN POPULATIONS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PROGRESS REPORT
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION