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The increase in animal mortality risk following exposure to sparsely ionizing radiation is not linear quadratic with dose

Journal Article · · PLoS ONE
 [1];  [2];  [3];  [2];  [4]
  1. Northwestern Univ., Chicago, IL (United States); Northwestern University
  2. Northwestern Univ., Chicago, IL (United States)
  3. Univ. of Chicago, Chicago, IL (United States)
  4. Univ. of Oklahoma, Norman, OK (United States)
+ Show Author Affiliations

The US government regulates allowable radiation exposures relying, in large part, on the seventh report from the committee to estimate the Biological Effect of Ionizing Radiation (BEIR VII), which estimated that most contemporary exposures- protracted or low-dose, carry 1.5 fold less risk of carcinogenesis and mortality per Gy than acute exposures of atomic bomb survivors. This correction is known as the dose and dose rate effectiveness factor for the life span study of atomic bomb survivors (DDREFLSS). As a result, it was calculated by applying a linear-quadratic dose response model to data from Japanese atomic bomb survivors and a limited number of animal studies.

Research Organization:
Northwestern Univ., Chicago, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
SC0001271
OSTI ID:
1240244
Journal Information:
PLoS ONE, Journal Name: PLoS ONE Journal Issue: 12 Vol. 10; ISSN 1932-6203
Publisher:
Public Library of ScienceCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (8)

Typical doses and dose rates in studies pertinent to radiation risk inference at low doses and low dose rates journal February 2018
Funding for radiation research: past, present and future journal February 2019
Radiation databases and archives – examples and comparisons journal October 2018
Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives journal April 2019
Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data journal October 2018
Reactor accident chemistry an update journal January 2018
Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives. text January 2019
Establishing the Japan-Store House of Animal Radiobiology Experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data text January 2019

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Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
animal studies
archives
bombs
carcinogenesis
death rates
dose prediction methods
ionizing radiation
radiation exposure