Cell cycle-dependent regulation of excision repair of UV damage
Journal Article
·
· Exp. Cell Res.; (United States)
The incinsion step of excision repair of UV-damaged DNA, represented by the accumulation of DNA strand breaks in the presence of hydroxyurea and 1-..beta..-D-arabinofuranosylcytosine, was measured in cultured cells of Microtus agrestis during quiescence and at different times after release from quiescence. The UV dose-dependent kinetics of enzymic incision change rapidly through the first cell cycle after release, with a maximum potential for enzymic incision and a minimum affinity of the incision system of damage sites occurring in late G1. The potential for incision falls to a lower level as cells approach a randomly proliferating state, whilst the affinity rises. Incision activity declines rapidly after UV irradiation, leaving many damage sites unrepaired; the enhanced survival seen in cells held in quiescence after irradiation is thus partly due to some other repair mode.
- Research Organization:
- Univ. of Cambridge, England
- OSTI ID:
- 5816969
- Journal Information:
- Exp. Cell Res.; (United States), Journal Name: Exp. Cell Res.; (United States) Vol. 142:1; ISSN ECREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Repair and survival after uv in quiescent and proliferating Microtus agrestis cells: different rates of incision and different dependence on DNA precursor supply
Role of ATP in UV-induced DNA excision repair in human cells
Cell cycle-related variations in uv damage and repair capacity in Chinese hamster (CHO-K1) cells. [69 ref]
Journal Article
·
Sat Mar 31 23:00:00 EST 1979
· J. Cell. Physiol.; (United States)
·
OSTI ID:6252609
Role of ATP in UV-induced DNA excision repair in human cells
Journal Article
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:7187861
Cell cycle-related variations in uv damage and repair capacity in Chinese hamster (CHO-K1) cells. [69 ref]
Journal Article
·
Thu May 01 00:00:00 EDT 1980
· J. Cell. Physiol.; (United States)
·
OSTI ID:5006911
Related Subjects
550301 -- Cytology-- Tracer Techniques
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
CELL CYCLE
CONNECTIVE TISSUE CELLS
DNA
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
FIBROBLASTS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
STRAND BREAKS
ULTRAVIOLET RADIATION
VERTEBRATES
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
CELL CYCLE
CONNECTIVE TISSUE CELLS
DNA
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
FIBROBLASTS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
STRAND BREAKS
ULTRAVIOLET RADIATION
VERTEBRATES