Congener specific biotransformation and bioaccumulation of PCDDs and PCDFs from fly ash in fish
- Univ. of Utrecht (Netherlands). Research Inst. of Toxicology, Environmental Chemistry Group
- Univ. of Amsterdam (Netherlands). Dept. of Environmental and Toxicological Chemistry
Biotransformation may be responsible for the lack of bioaccumulation of a number of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). Goldfish (Carassius auratus) that were exposed to PCDDs and PCDFs, and piperonylbutoxide (PBO) in water bioconcentrated significantly more congeners than goldfish exposed to PCDDs and PCDFs only. Monooxygenase activity, which is responsible for the oxidation of specific PCDD and PCDF congeners in untreated fish, was inhibited by fish treated with PBO. In the PBO-treated group and in the control group, congeners with all lateral positions substituted were found. Congeners that lack chlorine substitution on one or more of the lateral positions substituted were found. Congeners that lack chlorine substitution on one or more of the lateral (2,3,7,8) positions and congeners that have all lateral positions chlorinated were found only in PBO-treated fish. Congeners that have at least one free lateral position were therefore assumed to be biotransformed. There was no relationship between the octanol/water partition coefficient and biotransformed. There was no relationship between the octanol/water partition coefficient and biotransformation of the PCDDs and PCDFs. No limitation of uptake for higher chlorinated PCDD and PCDF congeners was found.
- OSTI ID:
- 5815643
- Journal Information:
- Environmental Toxicology and Chemistry; (United States), Vol. 12:10; ISSN 0730-7268
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOFURANS
TOXICITY
DIOXIN
GOLDFISH
SENSITIVITY
BIOLOGICAL ACCUMULATION
FLY ASH
WATER POLLUTION
AEROSOL WASTES
ANIMALS
AQUATIC ORGANISMS
ASHES
COMBUSTION PRODUCTS
FISHES
FURANS
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POLLUTION
RESIDUES
VERTEBRATES
WASTES
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology