Effect of 6-mercaptopurine on /sup 65/Zn distribution in the pregnant rat

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Teratology; (United States)

OSTI ID:5814786

Amemiya, K; Hurley, L S; Keen, C L

The effect of 6-mercaptopurine (6-MP) on the distribution of gavaged /sup 65/Zn in maternal and embryonic tissues of Sprague-Dawley rats was examined 24 hr after injection of the drug on day 13 of pregnancy. 6-MP injection resulted in a significantly higher retention of counts of /sup 65/Zn in maternal liver and lower counts in maternal plasma, uterus, placenta, and embryo than in controls. Compared to controls, gel chromatography of maternal liver from 6-MP injected dams showed higher counts associated with a protein peak of molecular weight 6,000-8,000, the approximate molecular weight of the zinc-binding protein metallothionein. These results support the idea that the zinc deficiency, which is observed in day 21 fetuses from dams injected with 6-MP during midgestation, may be the result of a drug-induced sequestering of zinc into maternal liver followed by a decrease in maternal plasma zinc and subsequent reduction in fetal zinc uptake. We suggest that this 6-MP-associated redistribution of zinc into maternal liver may be due to induction of maternal metallothionein synthesis by the drug.

• Research Organization: Univ. of California, Davis (USA)
• OSTI ID: 5814786
• Journal Information: Teratology; (United States), Journal Name: Teratology; (United States) Vol. 39:4; ISSN TJADA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CALCIUM
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EMBRYOS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PREGNANCY
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SEPARATION PROCESSES
SYNTHESIS
TERATOGENS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES