Lead toxicity in the pregnant rat
Journal Article
·
· Environ. Res.; (United States)
A study was made of the effects of administration of 500 ppm of lead in the drinking water of pregnant rats and their fetuses. The delta-aminolevulinic acid dehyratase (ALAD) activity of erythrocytes in the lead-treated fetuses showed 59.7 and 73.0% inhibition on Days 18 and 21 of pregnancy, respectively. ALAD activities in the liver and placenta were not significantly different between the lead-treated and control animals. The lead concentrations of blood and liver in the lead-treated dams and fetuses were higher than in the control animals, but the lead level of amniotic fluid was not significantly different from that of the control animals. Significant correlations were observed between maternal and fetal blood lead, liver lead, and erythrocyte ALAD, but there was no significant correlation between maternal and fetal liver ALAD.
- Research Organization:
- Dokkyo Univ. School of Medicine, Tochigi, Japan
- OSTI ID:
- 5504277
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 30:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
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· American Journal of Physiology; (USA)
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OSTI ID:5606131
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
AMNIOTIC FLUID
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ERYTHROCYTES
FETAL MEMBRANES
FETUSES
GLANDS
INHIBITION
LEAD
LIVER
MAMMALS
MATERIALS
MEMBRANES
METALS
ORGANS
PLACENTA
PREGNANCY
RATS
RODENTS
SENSITIVITY
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
AMNIOTIC FLUID
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ERYTHROCYTES
FETAL MEMBRANES
FETUSES
GLANDS
INHIBITION
LEAD
LIVER
MAMMALS
MATERIALS
MEMBRANES
METALS
ORGANS
PLACENTA
PREGNANCY
RATS
RODENTS
SENSITIVITY
TOXICITY
VERTEBRATES