Effects of high selenomethionine (L-SeMet) intakes on female long-tailed macaques and their offspring

Conference · Sun Mar 10 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5371028

Hawkes, W C; Craig, K A; Omaye, S T; Willhite, C C ^[1]

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1. USDA/ARS, San Francisco, CA (United States) Letterman Army Inst. of Research, San Francisco, CA (United States) Department of Health Services, Berkeley, CA (United States)

Pregnant females were treated daily for 30 days with 0, 25, 150 or 300 {mu}g Se as L-SeMet per kg body weight. Maternal Se toxicity was evident in the 150 and 300 {mu}g/kg-d groups. There were no effects of L-SeMet on pregnancy outcome, fetal morphology or neonatal development. Erythrocyte (RBC) glutathione peroxidase (GPx), RBC Se, plasma (PL) Se, PL GPx, hair (HR) Se, fecal Se and daily urinary Se excretion (UR Se) in dams were significantly correlated to L-SeMet intake. HR Se and UR Se showed the greatest responses to L-SeMet intake. RBC GPx increased 2.5-fold in the 150 {mu}g/kg-d group, casting doubt on use of RBC GPx saturation as a criterion of nutritional adequacy. Neonatal RBC and PL and fetal RBC, PL, liver, kidney, muscle and placental Se were significantly correlated to L-SeMet intake and maternal Se status, but GPx was not. There was no effect of L-SeMet on milk Se or milk GPx, showing the dominant effect of intrauterine exposure on neonatal Se status. PL Se was 3-fold higher in dams than in fetuses, suggesting a role of the placenta in regulating fetal Se. In control RBC and PL, fetal GPx {gt} neonatal GPx {gt} maternal GPx, suggesting an effect of development on GPx.

• OSTI ID: 5371028
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN 0892-6638; ISSN FAJOE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
FETUSES
GLUTATHIONE
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
MONKEYS
NEONATES
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PREGNANCY
PRIMATES
PROGENY
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SELENIUM
SEMIMETALS
TOXICITY
VERTEBRATES