Effect of valproic acid on /sup 65/Zn distribution in the pregnant rat

Journal Article · Sat Apr 01 04:00:00 EST 1989 · J. Nutr.; (United States)

OSTI ID:6146468

Keen, C L; Peters, J M; Hurley, L S

The effect of valproic acid on the distribution of gavaged /sup 65/Zn in maternal and embryonic tissue of Sprague-Dawley rats was examined 24 h after gavaging of the drug on d 13 of pregnancy. Valproic acid treatment resulted in a significantly higher retention of /sup 65/Zn in maternal liver and lower amounts in uterus, placenta and embryos than in controls. Compared to controls, gel chromatography of maternal liver from valproic acid-treated dams showed higher /sup 65/Zn counts associated with a protein peak of molecular weight of 6,500, the approximate molecular weight of the Zn-binding protein metallothionein. These results support the idea that the teratogenicity of valproic acid is in part due to an induction of embryonic Zn deficiency secondary to a drug-induced sequestering of Zn into maternal liver that results in a decrease in maternal plasma Zn and subsequent reduction in embryonic Zn uptake.

• Research Organization: Univ. of California, Davis (USA)
• OSTI ID: 6146468
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 119:4; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FEMALE GENITALS
FETAL MEMBRANES
FETUSES
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MEMBRANES
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MOLECULAR WEIGHT
MONOCARBOXYLIC ACIDS
NUCLEI
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PLACENTA
PREGNANCY
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SEPARATION PROCESSES
TERATOGENESIS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UTERUS
VALERIC ACID
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES