Effects of high dose intraperitoneal cytosine arabinoside on the radiation tolerance of the rat spinal cord
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effect of intraperitoneal high dose (9 g/kg) cytosine arabinoside (Ara-C) on the early delayed radiation response of the rat cervical spinal cord has been studied. When given 2 hrs before irradiation, systemically administered Ara-C significantly reduces the isoeffect doses for the induction of paralysis due to white matter necrosis by a factor of approximately 1.2 for both a single irradiation treatment and for a two fraction irradiation with 24 hr interval. No effect on the latency time to develop paralysis was recorded.
- Research Organization:
- Univ. Hospital St. Rafal, Leuven (Belgium)
- OSTI ID:
- 5814530
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 17:1; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
NECROSIS
NERVOUS SYSTEM
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SPINAL CORD
VERTEBRATES
WEIGHT
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
NECROSIS
NERVOUS SYSTEM
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SPINAL CORD
VERTEBRATES
WEIGHT