Radiation tolerance of the rat spinal cord: time-dose relationships. [X radiation]
Journal Article
·
· Radiology; (United States)
OSTI ID:7226177
The cervical or lumbosacral region of the rat spinal cord was irradiated with 300-kV x rays. Syndromes of radiation myelopathy similar to those in man were observed in the rats. Isoeffect curves for tolerance in relation to the number of fractions at daily intervals have a slope of 0.44 and 0.42 on a log-log scale for the cervical and lumbosacral regions, respectively. With intervals of up to 7 days, no significant further increase in tolerance was observed. Low dose rate treatments indicate a half-time of 1.5 hr for repair of subeffective damage. These results suggest that tolerance of the spinal cord depends very strongly on the number of fractions given and only to a small extent on the overall time of treatment.
- Research Organization:
- Radiobiological Inst., Rijswijk, Netherlands
- OSTI ID:
- 7226177
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 122:2; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NERVOUS SYSTEM
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPINAL CORD
TEMPORAL DOSE DISTRIBUTIONS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NERVOUS SYSTEM
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPINAL CORD
TEMPORAL DOSE DISTRIBUTIONS
VERTEBRATES
X RADIATION