Dose-latent period relationship in the irradiated cervical spinal cord of the rat. [250 kV x rays]

Journal Article · Fri Sep 01 04:00:00 EDT 1978 · Radiology; (United States)

OSTI ID:6951997

Hubbard, B M; Phil, D; Hopewell, J W

The cervical spinal cords of young adult female rats were irradiated with various single and fractionated doses of 250 kV x rays. No relationship was evident between the dose and the latent period for myelopathy after irradiation of the rats' cervical cords, i.e., there was considerable variation in the mean latent periods between different groups of animals given a fixed single dose (4,000 rads). It was concluded that the latent period for myelopathy following irradiation of the cervical cord of the rat is not a reliable experimental end point for radiobiological investigations.

• Research Organization: Churchill Hospital, Oxford
• OSTI ID: 6951997
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 128:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
INJURIES
IONIZING RADIATIONS
IRRADIATION
LATENCY PERIOD
LOCAL IRRADIATION
MAMMALS
MYELITIS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SPINAL CORD
VERTEBRATES
X RADIATION