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Dose effect relationship for epilation and late effects on spinal cord in rats exposed to gamma rays

Journal Article · · Radiology; (United States)
OSTI ID:7227701
The response of rat spinal cords exposed to single and multifractionated gamma-ray exposures revealed no significant differences between the threshold doses for 2 fractions given with a 24-hr interval and 2 fractions given with a 15-day interval. The latent period for spinal cord damage was about 190 days when the incidence of paralysis was high; it was less than this in animals with a lower probability of paralysis. There was a marked sparing effect from dose fractionation: the initial part of a Strandqvist type of isoeffect curve had a slope of 0.44 for doses causing paralysis in 50 percent of the animals, and 0.36 for threshold doses. The level of epilation was not useful for predicting spinal cord damage.
Research Organization:
M.D. Anderson Hospital and Tumor Inst., Houston, TX
OSTI ID:
7227701
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 122:1; ISSN RADLA
Country of Publication:
United States
Language:
English