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Effect of combinations of nitroaromatic and nitroxyl radiosensitizers on the radiation survival response of Chinese hamster cells, V. 79-753B, in vitro

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575668· OSTI ID:5807422
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The effect of various combinations of nitroaromatic (electron-affinic) and nitroxyl (free-radical) radiosensitizers on the radiation survival response of hypoxic Chinese hamster cells, V.79-753B, was studied. A bifunctional sensitizer posessing both a free-radical and an electron-affinic nitroarene, 1-(1-oxyl-2,2,6,6-tetramethyl-4-piperidy)amino-3-(2-nitro-1-imidazolyl)-2-propanol (Ro-03-9454), was also used. In all combinations tested there was evidence that there is competition between the two types of sensitizer. This competition accounts for the mixed functional compound Ro-03-9454 being less effective than the monofunctional compound RSU-4013 (1-(1-(2-cyano-2-propyl)oxy-2,2,6,6- tetramethyl-4-piperidyl)amino-3-(2-nitro-1-imidazolyl)-2-propanol), which does not have a nitroxyl group. In combinations of nitroaromatic sensitizers the situation is more complex.
Research Organization:
Inst. of Cancer Research, Sutton, England
OSTI ID:
5807422
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMAL CELLS
ANIMALS
AROMATICS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DRUGS
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
MAMMALS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROPANOLS
RADIATION EFFECTS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
VERTEBRATES