Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Radiat. Res., v. 65, no. 1, pp. 152-162

DOI:https://doi.org/10.2307/3574295· OSTI ID:4023303

Cooke, B C; Fielden, E M; Johnson, M; Smithen, C E

The effect of bis(2,2,6,6-Tetramethyl-1-oxyl-4-piperidinyl)succinate (Ro- 03-6061) on the survival parameters of V-79 Chinese hamster cells, irradiated under hypoxia, has been compared with related monofunctional nitroxyl compounds. The biradical is more effective in reducing the D$sub 0$ value than the three monoradical nitroxyls tested. It also removed the shoulder in asynchronous cell survival experiments, although this effect did not occur in the presence of oxygen. The shoulder for the survival curve for cells irradiated during late S phase was also reduced. Possible mechanisms for its actions are discussed in terms of the bifunctionality of the compound and the potential of such a sensitizer in radiotherapy is emphasized. (auth)

• Research Organization: Inst. of Cancer Research, Sutton, Eng
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-026153
• OSTI ID: 4023303
• Journal Information: Radiat. Res., v. 65, no. 1, pp. 152-162, Journal Name: Radiat. Res., v. 65, no. 1, pp. 152-162; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- BIOLOGICAL RADIATION EFFECTS
*RADICALS-- RADIOSENSITIVITY EFFECTS
560121* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--External Source
CELL CULTURES
COBALT 60
GAMMA RADIATION
IRRADIATION
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
SURVIVAL TIME