Polyfunctional radiosensitizers. II. Interaction of the biradical (Ro 03-6061) with reducing species. [Nor-pseudopelletierine-N-oxyl]
Journal Article
·
· Radiat. Res.; (United States)
- Inst. of Cancer Research, Sutton, Eng.
Preincubation of the biradical Ro 03-6061 with human erythrocytes rendered the molecule ineffective as a sensitizer of hypoxic V79 cells. The rate of reduction of the biradical with reduced glutathione proceeded much more slowly than that of the monoradical nitroxyl NPPN, and the reaction was faster at 37/sup 0/C than at room temperature. The reduction of the free radical centers was reflected in its radiosensitizing ability, causing changes in the survival curves of hypoxic V79 cells with respect to both D/sub 0/ and the extrapolation number. The efficacy of the biradical as a sensitizer was not completely removed by treatment with reduced glutathione at 37/sup 0/C whereas there was no sensitization of hypoxic cells in the presence of NPPN that had been pretreated similarly with reduced glutathione. The results are discussed in terms of the chemistry of the molecule and possible mechanistic differences between mono- and biradical nitroxyls, and other shoulder-modifying sensitizers such as diamide.
- OSTI ID:
- 5090191
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Polyfunctional radiosensitizers. III. Effect of the biradical (Ro-03-6061) in combination with other radiosensitizers on the survival of hypoxic V-79 cells. [Gamma radiation]
Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro
Polyfunctional radiosensitizers: VI. Dexamethasone inhibits shoulder modification by uncharged nitroxyl biradicals in mammalian cells irradiated in vitro
Journal Article
·
Mon Feb 28 23:00:00 EST 1977
· Radiat. Res.; (United States)
·
OSTI ID:7259834
Polyfunctional radiosensitizers. I. Effects of a nitroxyl biradical on the survival of mammalian cells in vitro
Journal Article
·
Wed Dec 31 23:00:00 EST 1975
· Radiat. Res., v. 65, no. 1, pp. 152-162
·
OSTI ID:4023303
Polyfunctional radiosensitizers: VI. Dexamethasone inhibits shoulder modification by uncharged nitroxyl biradicals in mammalian cells irradiated in vitro
Journal Article
·
Sat Oct 01 00:00:00 EDT 1983
· Radiat. Res.; (United States)
·
OSTI ID:5427927
Related Subjects
550200 -- Biochemistry
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL REACTIONS
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ERYTHROCYTES
FLUIDS
GAMMA RADIATION
GLUTATHIONE
IONIZING RADIATIONS
NONMETALS
ORGANIC COMPOUNDS
OXYGEN
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOSENSITIZERS
REDUCTION
RESPONSE MODIFYING FACTORS
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL REACTIONS
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
ERYTHROCYTES
FLUIDS
GAMMA RADIATION
GLUTATHIONE
IONIZING RADIATIONS
NONMETALS
ORGANIC COMPOUNDS
OXYGEN
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOSENSITIZERS
REDUCTION
RESPONSE MODIFYING FACTORS