Rapid screening of hazard (RASH) based on maximum use of biological data and minimum use of extrapolation models

Conference · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5806599

Jones, T D; Glass, L R; Easterly, C E; Owen, B A

Traditional methods for evaluation of human health effects are based on identification of the toxic agent, selection of a toxicological study judged to be a suitable analogue for man, analysis of the experimental dose response, incorporation of safety factors, and scaling of the dose and response values to be predictive for humans exposed to untested pollutants or under untested conditions. This method of absolute decision making derives from expert committees and regulatory standards for protection of human health. This work will describe how new relative methods can be used to supplement absolute methods used by the Environmental Protection Agency (EPA) to set regulatory standards and performance guidelines. Relative decision making uses many potency comparisons between various biological tests and minimizes the use of mathematical models commonly used to extrapolate dose and response metrics from past experience to future concerns. 10 refs., 2 figs., 5 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5806599
• Report Number(s): CONF-871075-27; ON: DE88002301
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR
ANIMALS
BIOLOGICAL EFFECTS
CARCINOMAS
COMPARATIVE EVALUATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
FLUIDS
GASES
HYDROGEN COMPOUNDS
MAMMALS
MATERIALS
MATHEMATICAL MODELS
NATIONAL ORGANIZATIONS
NEOPLASMS
OPTIMIZATION
ORNL
OXYGEN COMPOUNDS
RATS
REGULATIONS
RISK ASSESSMENT
RODENTS
TOXIC MATERIALS
US AEC
US DOE
US EPA
US ERDA
US ORGANIZATIONS
VERTEBRATES
WATER