Use of relative toxicity for risk estimation

Conference · Fri Jan 01 04:00:00 EST 1982

OSTI ID:5455500

Dudney, C S; Walsh, P J; Jones, T D; Calle, E E; Griffin, G D

Health effects assessment uses epidemiological, toxicological, and basic biological, biochemical, and biophysical data to estimate effects in humans to exposures of interest, or to rank a set of materials according to estimated human effects. Such methodology involves a number of very complex issues and must include estimates of: a human dose response function, the uncertainty in the estimated effects, the most probable range of risk as well as the upper limit risk, the predictive power of biological test systems used, comparative risks from other materials or sources, and data gaps, priorities, and research needs. A method has been developed based upon relative toxicological potency which incorporates these features.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5455500
• Report Number(s): CONF-820122-3; ON: DE82010200
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
HAZARDS
HEALTH HAZARDS
MATERIALS
RBE
RISK ASSESSMENT
TOXIC MATERIALS
TOXICITY