Cadmium absorption and tissue distribution in rats provided low concentrations of cadmium in food or drinking water

Journal Article · · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530062· OSTI ID:5805554

Buhler, D R; Wright, D C; Smith, K L; Tinsley, I J

Tissue Cd levels were determined 1, 2, 4, 8, and 12 weeks after weanling rats were provided with food or water containing 1-1000 ng/g Cd as /sup 109/CdCl/sub 2/. No differences in growth rate or organ weight were observed over the concentration range tested. Kidney accumulated the highest concentration of Cd, followed by liver with values one-third to one-fourth those found in the kidney. Liver, however, accounted for 35 to 55% of the total body burden, while kidney contained only 35 to 45%. Cd concentrations in the various tissues increased with time and the Cd concentration of the food or water. The percentage of the ingested dose absorbed in a given time was relatively constant over the tested Cd concentration range. However, for each metal concentration, the percent of Cd absorbed decreased with exposure time. Regression analysis established that female rats accumulated Cd at a higher rate and retained a greater percentage of the ingested Cd than did male rats and that tissue concentrations were higher in rats exposed to Cd in the water. The differences in tissue Cd levels are probably related to proportionally higher metal intake by females and to higher intkae from water than food at equivalent concentrations. It is uncertain whether the greater retention of ingested Cd by females is due to more efficient absorption or a reduced rate of excretion of the metal.

• Research Organization: Oregon State Univ., Corvallis
• OSTI ID: 5805554
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
COMPUTER CALCULATIONS
COUNTING TECHNIQUES
DATA
DIAGNOSTIC TECHNIQUES
DIET
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
ELECTRON CAPTURE RADIOISOTOPES
EVALUATED DATA
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HYDROGEN COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
OXYGEN COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
SEX DEPENDENCE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES