Effect of clofibrate on cholesterol metabolism in rats treated with polychlorinated biphenyls

Journal Article · Sat Feb 01 04:00:00 EST 1986 · Lipids; (United States)

DOI:https://doi.org/10.1007/BF02534439· OSTI ID:5800520

Nakagawa, M; Shimokawa, T; Noguchi, A; Ishihara, N; Kojima, S

Serum and hepatic cholesterol content in rats treated with polychlorinated biphenyls (PCBs, KC-400) were increased compared to those of control rats. This increase of cholesterol content was reduced to control level by simultaneous administration of ethyl p-chlorophenoxyisobutyrate (CPIB). Also, when lecithin-cholesterol acyltransferase (LCAT) activity was expressed as the net cholesterol esterification, the acyltransferase activity in rats treated with PCBs was elevated, while the elevated acyltransferase activity was brought to control level by simultaneous administration of CPIB. On the other hand, the amount of bile of rats treated with CPIB, PCBs and PCBs-CPIB was increased, but free and total cholesterol content in bile of these treated rats was decreased to 40-60% of those of control rats. Moreover, cytochrome P-450 content in liver microsomes of rats treated with CPIB, PCBs and PCBs-CPIB was increased. At the same time, cholesterol-metabolizing activity in liver microsomes of rats treated with CPIB, PCBs and PCBs-CPIB also was elevated. Similar results were obtained for drug metabolizing (aniline hydroxylation and aminopyrine N-demethylation) activity. In addition, the amount of bile acids excreted from rats treated with CPIB, PCBs and PCBs-CPIB was increased compared to that of control rats. These results suggest that hypercholesterolemia induced by oral ingestion of PCBs is recovered by CPIB treatment and that this hypocholesterolemic effect of CPIB may be related partly to the elevation of hepatic mixed function oxidase activity for cholesterol catabolism.

• Research Organization: Kumamoto Univ., Japan
• OSTI ID: 5800520
• Journal Information: Lipids; (United States), Journal Name: Lipids; (United States) Vol. 2; ISSN LPDSA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BILE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BUTYRIC ACID
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATED AROMATIC HYDROCARBONS
CHOLESTEROL
CYTOCHROMES
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
ESTERIFICATION
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HYDROXY COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLISM
MICROSOMES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
ORGANS
PIGMENTS
PROTEINS
RATS
RODENTS
STEROIDS
STEROLS
TRANSFERASES
VERTEBRATES