Effect of dimethyl sulfoxide on cholesterol and bile acid metabolism in rats

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-186-42604· OSTI ID:5378566

Hassan, A S

The effect of DMSO on cholesterol and bile acid metabolism was studied in rats. Male Sprague-Dawley rats were randomly assigned to one of two groups and given either tap water of 2% DMSO (v/v) in tap water to drink for 9 days. Both food and water were available ad libitum. Animals in both groups gained weight equally throughout the study. They also had similar liver weights at the end of the study. The activity of hepatic cholesterol 7..cap alpha..-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, was significantly reduced in the treated animals. Plasma cholesterol was significantly elevated in the treated animals, a finding consistent with the reduced CH-7..cap alpha.. hydroxylase activity in this group. DMSO treatment did not affect either microsomal cholesterol content or hepatic glutathione content. Thus, this study has shown that DMSO treatment per se can affect cholesterol and bile acid metabolism. However, the precise mechanisms whereby DMSO exerts the observed effects are not known.

• Research Organization: Univ. of Illinois, Urbana (USA)
• OSTI ID: 5378566
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 186:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BILE ACIDS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHOLESTEROL
DIGESTIVE SYSTEM
DMSO
ENZYME ACTIVITY
ENZYMES
GLANDS
HYDROXY COMPOUNDS
HYDROXYLASES
LIVER
MAMMALS
METABOLISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
STEROIDS
STEROLS
SULFOXIDES
VERTEBRATES