Effects of carbadox, a synthetic antimicrobial agent, on bile acid metabolism in the domestic pig
Thesis/Dissertation
·
OSTI ID:5148244
Radiolabeled chenodeoxycholic acid (CDC) was infused into the hepatic portal vein (HP) and fluctuations of the plasma radioactivities of CDC and its metabolites were monitored in young unrestrained pigs. There was a significant difference in the plasma radioactivity between the morning and evening meals from both vena cava and portal vein plasma samples. To study the effects of an antimicrobial feed additive on bile acid metabolism, carbadox (CX) was added to a 19.5% corn-soybean ration and fed to young pigs. CX at 58 ppm affected apparent clearance of CDC from the HP blood. The plasma concentrations of the bile acids were higher in the animals fed CX. Plasma fluctuations of the bile acids in response to meals showed that the plasma bile acid concentrations following feeding at 1600 hours were greater than those following feeding at 0800 hours. The rate of excretion of the bile acids in the feces was increased and biological half-life of CDC decreased to 5.7 in the CX-fed pigs from 6.4 days in the controls. The feeding of CX did not significantly affect the activity of cholesterol 7..cap alpha..-hydroxylase (CH-7..cap alpha..), the rate-limiting enzyme for bile acid synthesis.
- Research Organization:
- Illinois Univ., Urbana (USA)
- OSTI ID:
- 5148244
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
BILE ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BLOOD-PLASMA CLEARANCE
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
DATA
DOMESTIC ANIMALS
DRUGS
ENZYMES
EXCRETION
EXPERIMENTAL DATA
FECES
HYDROXY COMPOUNDS
HYDROXYLASES
INFORMATION
INGESTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
STEROIDS
STEROLS
SWINE
TRACER TECHNIQUES
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
BILE ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BLOOD-PLASMA CLEARANCE
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
DATA
DOMESTIC ANIMALS
DRUGS
ENZYMES
EXCRETION
EXPERIMENTAL DATA
FECES
HYDROXY COMPOUNDS
HYDROXYLASES
INFORMATION
INGESTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
STEROIDS
STEROLS
SWINE
TRACER TECHNIQUES
VERTEBRATES
WASTES