Erythrocytes in muscular dystrophy. Investigation with 31P nuclear magnetic resonance spectroscopy

Journal Article · Fri May 01 04:00:00 EDT 1981 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1981.00510050037003· OSTI ID:5798922

Sarpel, G; Lubansky, H J; Danon, M J; Omachi, A

Phosphorus 31 nuclear magnetic resonance (31P NMR) signals were recorded from intact human erythrocytes for 16 hours. Total phosphate concentration, which was estimated as the sum of the individual 31P signals, was 25% lower in erythrocytes from men with myotonic dystrophy than in control erythrocytes. The inorganic-phosphate fraction contained the highest average phosphate concentration over the 16-hour period, and made the major contribution to the difference in total phosphate between the two groups. This result was not observed in erythrocytes from either women with myotonic dystrophy or patients with Duchenne's dystrophy and may be due to a change in cell membrane permeability to inorganic phosphate, which lead to lower steady-state concentrations of the intracellular phosphates.

• Research Organization: Univ. of Illinois, Chicago
• OSTI ID: 5798922
• Journal Information: Arch. Neurol.; (United States), Journal Name: Arch. Neurol.; (United States) Vol. 38:5; ISSN ARNEA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550301 -- Cytology-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
DIAGNOSIS
ERYTHROCYTES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MATERIALS
MEMBRANES
MUSCLES
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
PATIENTS
PERMEABILITY
PHOSPHATES
PHOSPHORUS 31
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
RESONANCE
SEX DEPENDENCE
STABLE ISOTOPES