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Erythrocytes in muscular dystrophy. Investigation with /sup 31/P nuclear magnetic resonance spectroscopy

Journal Article · · Arch. Neurol.; (United States)
; ; ;
Phosphorus 31 nuclear magnetic resonance (/sup 31/P NMR) signals were recorded from intact human erythrocytes for 16 hours. Total phosphate concentration, which was estimated as the sum of the individual /sup 31/P signals, was 25% lower in erythrocytes from men with myotonic dystrophy than in control erythrocytes. The inorganic-phosphate fraction contained the highest average phosphate concentration over the 16-hour period, and made the major contribution to the difference in total phosphate between the two groups. This result was not observed in erythrocytes from either women with myotonic dystrophy or patients with Duchenne's dystrophy and may be due to a change in cell membrane permeability to inorganic phosphate, which leads to lower steady-state concentrations of the intracellular phosphates.
OSTI ID:
5515851
Journal Information:
Arch. Neurol.; (United States), Journal Name: Arch. Neurol.; (United States) Journal Issue: 5 Vol. 38:5; ISSN ARNEA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
DIAGNOSTIC USES
DISEASES
ERYTHROCYTES
HEREDITARY DISEASES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MATERIALS
MEMBRANES
MUSCLES
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
PERMEABILITY
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RESONANCE
STABLE ISOTOPES
TIME DEPENDENCE
TRACER TECHNIQUES
USES