3-Methylhistidine excretion in myotonic dystrophy

Journal Article · Sun Nov 30 23:00:00 EST 1980 · Neurology; (United States)

OSTI ID:5728776

Griggs, R C; Moxley, III, R T; Forbes, G B

3-Methylhistidine (3-MH) excretion reflects the rate of muscle protein catabolism, since 3-MH occurs almost exclusively in muscle actin and myosin and is not reutilized or catabolized. We studied 3-MH excretion in 9 patients with myotonic dystrophy, 8 normals, and 10 disease controls with Duchenne dystrophy and other disorders. 3-MH excretion was expressed relative to muscle mass as determined by both urinary creatinine and total body potassium (/sup 40/K method). Absolute 3-MH excretion was decreased in myotonic dystrophy patients but was normal when related to muscle mass. The finding of normal 3-MH excretion in myotonic dystrophy suggests that the muscle wasting in this disorder results from impaired anabolic processes rather than accelerated muscle destruction.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 5728776
• Journal Information: Neurology; (United States), Journal Name: Neurology; (United States) Vol. 30:12; ISSN NEURA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIN
ALKALI METAL ISOTOPES
AMINO ACIDS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CARBOXYLIC ACIDS
CATABOLISM
CHEMISTRY
CLEARANCE
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
GLOBULINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
IMIDAZOLES
ISOTOPES
LIGHT NUCLEI
METABOLIC DISEASES
METABOLISM
METABOLITES
MUSCLES
MYOSIN
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
POTASSIUM 40
POTASSIUM ISOTOPES
PROTEINS
RADIOISOTOPES
USES
YEARS LIVING RADIOISOTOPES