Vascular adrenergic receptor responses in skeletal muscle in myotonic dystrophy

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410090209· OSTI ID:5504395

Mechler, F; Mastaglia, F L

The pharmacological responses of vascular adrenergic receptors to intravenously administered epinephrine, phentolamine, and propranolol were assessed by measuring muscle blood flow (MBF) changes in the tibialis anterior muscle using the xenon 133 clearance technique and were compared in 8 normal subjects and 11 patients with myotonic dystrophy. In cases with advanced involvement of the muscle, the resting MBF was reduced and was not significantly altered by epinephrine before or after alpha- or beta-receptor blockade. In patients in whom the tibialis anterior muscle was normal or only minimally affected clinically, a paradoxical reduction in the epinephrine-induced increase in MBF was found after alpha blockade by phentolamine, and the epinephrine-induced MBF increase was not completely blocked by propranolol as in the normal subjects. These findings point to functional alteration in the properties of vascular adrenergic receptors in muscle in myotonic dystrophy. While this may be another manifestation of a widespread cell membrane defect in the disease, the possibility that the changes are secondary to the myotonic state cannot be excluded.

• OSTI ID: 5504395
• Journal Information: Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 9:2; ISSN ANNED
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALINE
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CELL MEMBRANES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DRUGS
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEMBRANES
MUSCLES
NEUROREGULATORS
NUCLEI
PATHOLOGY
PATIENTS
RADIOISOTOPES
RECEPTORS
STEROID HORMONES
SYMPATHOMIMETICS
USES
VASCULAR DISEASES
XENON 133
XENON ISOTOPES