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Evidence for mild thyroidal impairment in women undergoing endurance training

Journal Article · · J. Clin. Endocrinol. Metab.; (United States)
DOI:https://doi.org/10.1210/jcem-54-1-53· OSTI ID:5795731
 [1]; ; ; ;
  1. Univ. of Arizona, Tucson
+ Show Author Affiliations
The effects of endurance training on body composition and the pituitary-thyroid axis were studied in 29 healthy, young (mean age, 28.7 yr), regularly menstruating women. Women who were initially jogging a mean of 13.5 miles/week were selected for this study to minimize dropouts. Body composition, measured by hydrostatic weighing, and nonfasting plasma concentrations of T/sub 4/, T/sub 3/, rT/sub 3/, TSH, and TRH-stimulated TSH, measured by RIA, were examined initially and after each subject's weekly mileage had increased to 30 miles (..delta..30, mean total body weight did not change, mean fat weight decreased (-1.02 kg/ P<0.005), and mean lean weight increased (+0.75 kg; P<0.05). T/sub 4/ and unstimulated TSH did not change. However, mean (+/- SE) T/sub 3/ decreased from 107.2 +/- 4.4 to 97.9 +/- 3.4 ng/dl (P<0.025), and mean rT/sub 3/ decreased from 170.9 +/- 13.9 to 154.6 +/- 13.2 pg/ml (P<0.025). The decrease in T/sub 3/ and rT/sub 3/ were accompanied by significantly greater TSH responses to TRH stimulation (mean (+/- SE) area under TSH curve, 1381.4 +/- 123 vs. 1712.8 +/- 202 ..mu..IU/ml-min; P < 0.01). These results indicate that physically active women who undergo additional endurance training 1) become more lean without a change in total body weight, and 2) have changes in T/sub 3/, rT/sub 3/, and TRH-stimulated TSH indicative of mild thyroidal impairment.
OSTI ID:
5795731
Journal Information:
J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 54:1; ISSN JCEMA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BODY
BODY COMPOSITION
CARBOXYLIC ACIDS
DATA
ENDOCRINE GLANDS
EXERCISE
EXPERIMENTAL DATA
FEMALES
GLANDS
HORMONES
INFORMATION
ISOTOPE APPLICATIONS
MAMMALS
MAN
METABOLISM
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
THYROID
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES
TRH
TRIIODOTHYRONINE
TSH
VERTEBRATES
WOMEN