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The spectrum of inappropriate pituitary thyrotropin secretion associated with hyperthyroidism

Journal Article · · Mayo Clin., Proc.; (United States)
OSTI ID:6708652
; ;

Two patients with overproduction of thyroid-stimulating hormone (TSH) are described. The first patient, a 25-year-old man with recurrent hyperthyroidism, had a pituitary adenoma and highly elevated levels of TSH. While the patient was receiving 0.3 mg of thyroid daily, and basal TSH level was 161 microM/ml. Despite an increase in the thyroid hormone therapy, serum TSH levels remained elevated. The administration of thyrotropin-releasing hormone (TRH) or dexamethasone resulted in no changes in TSH level. The second patient was an 18-year-old man who had inappropriately elevated levels of TSH 3 months after radioiodine therapy for hyperthyroidism. A gradual increase in thyroid hormone replacement therapy decreased the serum TSH levels from 250 to 14.8 microM/ml. The administration of TRH led to huge increases of TSH. Dexamethasone inhibited basal TSH but not TRH-stimulated TSH levels. The overproduction of TSH was attributed to autonomous, neoplastic secretion in the first case and to partial, selective pituitary thyrotroph resistance to thyroid hormone in the second.

Research Organization:
Division of Endocrinology
OSTI ID:
6708652
Journal Information:
Mayo Clin., Proc.; (United States), Journal Name: Mayo Clin., Proc.; (United States) Vol. 57:9; ISSN MACPA
Country of Publication:
United States
Language:
English

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Related Subjects

550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
DIAGNOSIS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYPERTHYROIDISM
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
THYROID
TRH
TSH