Radiation-induced. cap alpha. -thalassemia in mice

Journal Article · Sat Jan 01 00:00:00 EST 1977 · Am. J. Vet. Res.; (United States)

OSTI ID:5792267

Popp, R A; Enlow, M K

The clinical hematologic change in 2 groups of progeny from mice carrying radiation-induced strain SEC ..cap alpha..-chain deficiencies was found to be similar to the hematologic alterations in persons with ..cap alpha..-thalassemia. The heterozygous deletion or inactivation of the ..cap alpha..-chain gene in mice caused an anemia similar to ..cap alpha..-thalassemina minor in persons. The ..cap alpha..-chain deficiency in mice created an erythrocytosis, reticulocytosis, and microcytic, hypochromic anemia comparable with the changes in human ..cap alpha..-thalassemia minor resulting from deletion of the ..cap alpha..-chain gene. These mouse mutants are the only known animal models of human thalassemia. A comparison of hematologic values obtained from progeny possessing an ..cap alpha..-chain gene deficiency and from progeny possessing a ..beta..-chain duplication suggested that the deficiency of ..cap alpha..-chain synthesis, rather than a simple imbalance between the amounts of ..cap alpha..- and ..beta..-chains produced, was primarily responsible for the altered hematologic characteristics in these ..cap alpha..-thalassemic mice.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 5792267
• Journal Information: Am. J. Vet. Res.; (United States), Vol. 38:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
THALASSEMIA
BIOLOGICAL MODELS
ANEMIAS
GENE MUTATIONS
GENETIC RADIATION EFFECTS
HEMIC DISEASES
MICE
PATHOLOGICAL CHANGES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
GENETIC EFFECTS
MAMMALS
MUTATIONS
RADIATION EFFECTS
RODENTS
SYMPTOMS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550400 - Genetics