Erythrocyte life span in alpha thalasemic mice

Journal Article · Sat Dec 31 23:00:00 EST 1977 · Birth Defects, Orig. Artic. Ser.; (United States)

OSTI ID:6509829

Popp, R A; Francis, M C; Bradshaw, B S

As mice mature and become senescent, they often become anemic. The basis for the anemia is not well known; however, several types of anemia in humans are associated with a marked shortening in the life span of the erythrocytes. Recently, a mouse model of an inherited anemia in humans, namely ..cap alpha..-thalassemia minor, was induced by X irradiation. These mice exhibit a microcytic, hypochromic anemia with erythrocytosis and reticulocytosis. We report here that the erythrocytes of ..cap alpha..-thalassemic mice do have a shortened life span, and we speculate on the role this could have on the life shortening of these genetically anemic animals.

• OSTI ID: 6509829
• Journal Information: Birth Defects, Orig. Artic. Ser.; (United States), Journal Name: Birth Defects, Orig. Artic. Ser.; (United States) Vol. XIV:1; ISSN BTHDA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
DISEASES
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
HEMIC DISEASES
IONIZING RADIATIONS
LIFE SPAN
MAMMALS
MICE
RADIATIONS
RETICULOCYTES
RODENTS
SYMPTOMS
THALASSEMIA
VERTEBRATES
X RADIATION