Erythrocyte life span in alpha thalassemic mice

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:7131031

Popp, R A; Francis, M C; Bradshaw, B S

As mice mature and become senescent, they often become anemic. The basis for the anemia is not well known; however, several types of anemia in humans are associated with a marked shortening in the life span of the erythrocytes. Recently. a mouse model of an inherited anemia in humans, namely ..cap alpha.. thalassemia minor, was induced by X irradiation. These mice exhibit a microcytic, hypochromic anemia with erythrocytosis and reticulocytosis. We report here that the erythrocytes of ..cap alpha.. thalassemic mice do have a shortened life span and we speculate on the role this could have on the life shortening of these genetically anemic animals.

• Research Organization: Oak Ridge National Lab., Tenn. (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7131031
• Report Number(s): CONF-760947-2
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
551000* -- Physiological Systems
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANEMIAS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONGENITAL DISEASES
DISEASES
ERYTHROCYTES
ETIOLOGY
GENETIC CONTROL
HEMIC DISEASES
LIFE SPAN
MAMMALS
MICE
PEST CONTROL
RADIOINDUCTION
RODENTS
SYMPTOMS
THALASSEMIA
VERTEBRATES