Rapid solubilization and translocation of /sup 109/CdO following pulmonary deposition. [Rats]
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
In order to examine the translocation of CdO from the respiratory surfaces rats were given an intratracheal instillation of cadmium oxide tagged with /sup 109/Cd. The half-life of the /sup 109/Cd in lung was about 4 h, at which time nearly 40% of the /sup 109/Cd body burden was in the liver. At 24 h following instillation, the distribution of /sup 109/Cd was: lung, 23.9%; liver, 58.4%; kidney, 2.7%; and testes, 0.22%. At 2 weeks after instillation the lung, liver, and kidney had 18, 57, and 8% respectively, of the body burden. Less than 10% of the instilled /sup 109/Cd was excreted during the first 2 weeks. These data suggest that inhaled CdO is highly soluble in the lung but that cadmium is slowly excreted from the body, resulting in a long-term dose commitment to several tissues.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- DOE Contract Number:
- EY-76-C-06-1830
- OSTI ID:
- 5791516
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 54; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
CADMIUM OXIDES
CHALCOGENIDES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE COMMITMENTS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
GONADS
INTERMEDIATE MASS NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLUBILITY
TESTES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSLOCATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
CADMIUM OXIDES
CHALCOGENIDES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE COMMITMENTS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
GONADS
INTERMEDIATE MASS NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLUBILITY
TESTES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSLOCATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES