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Pulmonary clearance of intratracheally administered /sup 63/Ni/sub 3/S/sub 2/ in strain A/J mice

Journal Article · · Environ. Res.; (United States)
OSTI ID:5971579
;
The pulmonary clearance of particulate /sup 63/Ni/sub 3/S/sub 2/ was evaluated in strain A/J mice following the intratracheal instillation of 3 ..mu..Ci of /sup 63/Ni/sub 3/S/sub 2/ (1.66 ..mu..m, mass median diameter). Lung and tissue burdens were determined from serially sacrificed animals using scintillation counting techniques. Lung clearance over the 35-day observation period could be separated into two distinct components with initial and final phase biological half-times corresponding to 1.2 and 12.4 days, respectively. Radioactivity was detected in the blood, liver, kidney, and femur within 4 hr, and was eliminated at rates comparable to that in the lung. Excretion involved primarily urinary (60% of dose eliminated) but also fecal (40% of dose eliminated) pathways. The data are consistent with the relatively rapid translocation, solubilization, and elimination of particulate /sup 63/Ni/sub 3/S/sub 2/ from the body.
Research Organization:
New York Univ. Medical Center, NY
OSTI ID:
5971579
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHALCOGENIDES
CLEARANCE
COUNTING TECHNIQUES
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FEMUR
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTRATRACHEAL ADMINISTRATION
ISOTOPES
KIDNEYS
LIVER
LUNG CLEARANCE
MAMMALS
MATERIALS
MICE
NICKEL 63
NICKEL COMPOUNDS
NICKEL ISOTOPES
NICKEL SULFIDES
NUCLEI
NUMERICAL DATA
ORGANS
PARTICLES
PARTICULATES
RADIOISOTOPES
RODENTS
SCINTILLATION COUNTING
SKELETON
SULFIDES
SULFUR COMPOUNDS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES