Pulmonary clearance and hilar lymph node content in rats after particle exposure
The alveolo-bronchial and the lymphatic pathways are most important in pulmonary clearance of relatively insoluble particles. We were interested in studying the effect of the lung burden on the size of the fraction cleared via the lymphatic system. TiO/sub 2/ particles, representing the ''inert and insoluble'' class of particulate matter, were used in rats utilizing both intratracheal instillation and inhalation exposures. After a single exposure about 40 to 45% of the deposited particles are cleared from the lung in 25 days and about 0.7% are found in the hilar lymph nodes at low exposures. At high exposures lung clearance decreases, in some experiments to zero values, and the lymph node content increases to 4%. At low exposures both exposure techniques result in similar clearance values; however, the lymphatic node content rises with increased lung burden faster after intratracheal instillation. The possible mechanisms involved are discussed.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 5912426
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 16; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BODY
CHALCOGENIDES
CLEARANCE
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
INHALATION
INTAKE
INTRATRACHEAL ADMINISTRATION
LUNG CLEARANCE
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
POLLUTION
RATS
RESPIRATORY SYSTEM
RODENTS
TITANIUM COMPOUNDS
TITANIUM OXIDES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES