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Kinetics of reparative DNA replication induced in CBA and C57BL/6 mouse spleen cells by urethane and influenza virus

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00834409· OSTI ID:5783255
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The authors investigated the reparative replication of DNA, induced by urethane and influenza virus in C57BL/6 and CBA mice which have marked differences in tumor formation. Reparative DNA replication, induced by urethane and influenza virus was investigated by a liquid scintillation method based on measuring incorporation of /sup 3/H-thymidine into the total mass of mouse spleen cells, when replicative DNA synthesis was inhibited by hydroxyurea. The intensity of reparative DNA replication was judged from the value of the stimulation index which is the ratio of the radioactivity in the spleen cells of the experimental animals to the corresponding parameters in cells of intact animals. The phenomenon of the stimulating and inhibitory effects of influenza virus on reparative DNA replication in cells depending on their genotype and sensitivity to virus is established.
Research Organization:
L. V. Gromashevskii Kiev Research Institute of Epidemiology and Infectious Diseases, USSR
OSTI ID:
5783255
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 101:4; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550301 -- Cytology-- Tracer Techniques
550401* -- Genetics-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENESIS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DNA REPLICATION
HETEROCYCLIC COMPOUNDS
INFLUENZA VIRUSES
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PATHOGENESIS
PYRIMIDINES
RADIOACTIVITY
REACTION KINETICS
RECOVERY
REPAIR
RIBOSIDES
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
SPLEEN CELLS
STIMULATION
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
UPTAKE
URETHANE
VERTEBRATES
VIRUSES