Fowl plague virus replication in mammalian cell-avian erythrocyte heterokaryons: studies concerning the actinomycin D and ultra-violet lig sensitive phase in influenza virus replication

Journal Article · Sun Sep 01 04:00:00 EDT 1974 · Virology, v. 61, no. 1, pp. 210-222

DOI:https://doi.org/10.1016/0042-6822(74)90255-4· OSTI ID:4157724

Kelly, D C; Dimmock, N J

The replication of fowl plague virus in BHK and L cells specifically blocked prior to infection with inhibitors of influenza virus replication (actinomycin D and ultraviolet light irradiation) has been studied by the introduction of a metabolically dormant avian erythrocyte nucleus. This permits the synthesis of just the influenza virus nucleoprotein in actinomycin D (but not ultraviolet light) blocked cells. The NP antigen is first detected in the avian erythrocyte nucleus and subsequently in the heterokaryon cytoplasm. (auth)

• Research Organization: Univ. of Warwick, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-007448
• OSTI ID: 4157724
• Journal Information: Virology, v. 61, no. 1, pp. 210-222, Journal Name: Virology, v. 61, no. 1, pp. 210-222; ISSN VIRLA
• Country of Publication: United States
• Language: English

Related Subjects

*ACTINOMYCIN-- BIOLOGICAL EFFECTS
*INFLUENZA VIRUSES-- BIOLOGICAL RADIATION EFFECTS
560131* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Microorganisms--Basic Studies
ANIMAL CELLS
CELL PROLIFERATION
ERYTHROCYTES
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
ULTRAVIOLET RADIATION
VIRUSES