Scaling physiological pharmacokinetic models by physiological time

Conference · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5777527

Ward, R C; Travis, C C

This paper shows that a multicompartment physiological pharmacokinetic model, used to account for inhalation exposure to volatile chlorohydrocarbons in mammalian species, can be made species-independent if chronological time is re-expressed in terms of physiological time. Physiological time is defined as chronological time divided by species body weight to the 1/4 power. We demonstrate the usefulness of this time scaling of the multicompartment physiological pharmacokinetic model by using it to model the inhalation of the volatile chlorinated hydrocarbon tetrachloroethylene in mice, rats, and humans. 8 refs., 2 figs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5777527
• Report Number(s): CONF-880218-1; ON: DE88000335
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL FUNCTIONS
BLOOD FLOW
CHLORINATED ALIPHATIC HYDROCARBONS
FUNCTIONS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
MAN
MATHEMATICAL MODELS
MICE
OPTIMIZATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PHARMACOLOGY
PHYSIOLOGY
PRIMATES
RATS
RODENTS
SCALING
TIME DEPENDENCE
VERTEBRATES