Physiological pharmacokinetic modeling of inhalation exposure of tetrachloroethylene in rats and humans

Conference · Wed Jan 01 04:00:00 EST 1986

OSTI ID:5487968

Hetrick, D M; Ward, R C; Travis, C C

A physiologically-based pharmacokinetic model which incorporates biophysical parameters such as breathing and blood flow rates, blood and tissue volumes, and chemical partition coefficients is described. The model is used to predict chemical transport and metabolism in rats and humans for tetrachloroethylene, a chemical used extensively as a dry cleaning solvent. The concept of using body weight scaling of the physiological parameters is used to extrapolate results for exhaled air from rats to humans. Model results for inhalation of tetrachloroethylene are compared to empirical data for both species. 12 refs., 3 figs., 4 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5487968
• Report Number(s): CONF-860729-1; ON: DE86008239
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
CHLORINATED ALIPHATIC HYDROCARBONS
DATA
EXPERIMENTAL DATA
HALOGENATED ALIPHATIC HYDROCARBONS
INFORMATION
INHALATION
INTAKE
KINETICS
MAMMALS
METABOLISM
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
REACTION KINETICS
RODENTS
VERTEBRATES