Use of pharmacokinetics in risk analysis
Conference
·
OSTI ID:5718438
Quantitative risk assessment for carcinogenic chemicals is usually based on data obtained in animal studies conducted at very high levels of exposure. A key issue in using such data is extrapolation of the results from animals to man. Recently, physiological pharmacokinetic (P-P) models have been used to improve the accuracy of such extrapolations. Model results for inhalation of tetrachloroethylene will be presented and compared to experimental data for rats and humans. Scaling physiological parameters allowed us to successfully extrapolate results from rats to humans.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5718438
- Report Number(s):
- CONF-860626-1; ON: DE86010033
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MODELS
CARCINOGENS
CHLORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
KINETICS
MAMMALS
MAN
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
POLYETHYLENES
POLYMERS
POLYOLEFINS
PRIMATES
RATS
REACTION KINETICS
RISK ASSESSMENT
RODENTS
VERTEBRATES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MODELS
CARCINOGENS
CHLORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
KINETICS
MAMMALS
MAN
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
POLYETHYLENES
POLYMERS
POLYOLEFINS
PRIMATES
RATS
REACTION KINETICS
RISK ASSESSMENT
RODENTS
VERTEBRATES