Use of pharmacokinetics in risk analysis
Conference
·
· Trace Subst. Environ. Health; (United States)
OSTI ID:6064235
Quantitative risk assessment for carcinogenic chemicals is usually based on data obtained in animal studies conducted at very high levels of exposure. A key issue in using such data is extrapolation of the results from animals to man. Recently, physiological pharmacokinetic (P-P) models have been used to improve the accuracy of such extrapolations. Model results for inhalation of tetrachloroethylene will be presented and compared to experimental data for rats with humans. Scaling physiological parameters allowed them to successfully extrapolate results from rats to humans. 10 references, 3 figures, 4 tables.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6064235
- Report Number(s):
- CONF-860626-
- Conference Information:
- Journal Name: Trace Subst. Environ. Health; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARCINOGENESIS
CHLORINATED ALIPHATIC HYDROCARBONS
EXTRAPOLATION
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
KINETICS
MAMMALS
MAN
MATHEMATICAL MODELS
NUMERICAL SOLUTION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
PRIMATES
REACTION KINETICS
RISK ASSESSMENT
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARCINOGENESIS
CHLORINATED ALIPHATIC HYDROCARBONS
EXTRAPOLATION
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
KINETICS
MAMMALS
MAN
MATHEMATICAL MODELS
NUMERICAL SOLUTION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
PRIMATES
REACTION KINETICS
RISK ASSESSMENT
TOXICITY
VERTEBRATES