Sunlight suppressing rejection of 280- to 320-nm UV-radiation-induced skin tumors in mice
Repeated exposure of female C3H/HeNCR- mice to sunlight prevented the normal immunologic rejection of a UV-induced tumor. This systemic immunologic alteration was transferred to syngeneic lethally X-irradiated animals with lymphoid cells from mice exposed to sunlight. The lymphoid cells also were able to suppress the capacity of lymphoid cells from normal animals to reject a UV-induced tumor. The 295- to 320-nm wave band appeared to be responsible for this immunosuppressive effect of sunlight because suppression was prevented by filtration of the radiation through Mylar and by application of a sunscreen containing para-aminobenzoic acid. These observations may have importance in understanding the pathogenesis of sunlight-induced skin cancer in humans.
- Research Organization:
- NCI-Frederick Cancer Research Facility, MD
- OSTI ID:
- 5776694
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 74:2; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
VERTEBRATES
VISIBLE RADIATION
X RADIATION