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Repair of sublethal damage in diploid human fibroblasts: a compoarison between human and rodent cell lines

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576263· OSTI ID:5775144
; ;
Two diploid cell lines of human origin were irradiated in vitro. Repair of sublethal damage was observed in both lines when they were exposed to a single ..gamma..-ray dose and incubated at 37/sup 0/C prior to receiving a graded second dose. In addition cells were irradiated at a low dose rate (56 or 76 rad/hr) and survival was compared to that after an acute exposure. A dose-rate effect was demonstrated. Sublethal damage repair was also studied using CHO or V-79 Chinese hamster cells, and the data suggest that the degree of repair is similar in human and rodent cell lines at photon doses up to 500 rad. The repair of sublethal damage can be a significant factor in the survival of human cells in vitro for fractionated doses.
Research Organization:
Columbia Univ., New York, NY
DOE Contract Number:
AC02-78EV04733
OSTI ID:
5775144
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 95:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HAMSTERS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
SURVIVAL CURVES
VERTEBRATES
YEARS LIVING RADIOISOTOPES