Mucociliary clearance of inhaled particles measured at 2 h after ozone exposure in humans

Technical Report · Wed Sep 25 04:00:00 EDT 1991

OSTI ID:5771991

Gerrity, T R; Bennett, W D; Kehrl, H; DeWitt, P J

Acute exposure of humans to ozone is known to acutely cause pulmonary function decrements, inflammation, and increased permeability of pulmonary epithelium. Fifteen healthy male and female nonsmoking subjects were exposed, on different occasions, to clean air and 0.4 ppm ozone for 1 hour while they exercised continuously. Pulmonary function was measured immediately before and after exposure and 90 min and 24 hours after exposure. Each subject returned the next day for a final particle retention measurement. Despite significant changes in pulmonary function, there was no difference in mean whole lung retention time of particles between clean air and ozone exposures, indicating that mucociliary transport is unaffected by ozone exposure when it is measured 2 hours after exposure.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
• OSTI ID: 5771991
• Report Number(s): PB-93-236396/XAB; EPA--600/J-93/402
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AIR POLLUTION
ANIMAL TISSUES
BODY
ENVIRONMENTAL EFFECTS
EPITHELIUM
INFLAMMATION
OZONE
PARTICLES
PATHOLOGICAL CHANGES
PERMEABILITY
POLLUTION
SYMPTOMS
TISSUES
TOXICITY