Sulfur dioxide and tracheobronchial clearance in man

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1975.10666769· OSTI ID:7195025

Wolff, R K; Dolovich, M; Rossman, C M; Newhouse, M T

Tracheobronchial clearance was measured in nine healthy, nonsmoking adults. Technetium (/sup 99m/Tc) albumin aerosol (mass median diameter, 3..mu..; geometric standard deviation, 1.6) was inhaled as a bolus under controlled conditions to achieve reproducible deposition in large airways. Each subject was studied in three separate three-hour experiments: twice under control conditions and once exposed to 5 ppm sulfur dioxide (pollutant exposure after aerosol inhalation). Lung retention of activity was measured using a gamma camera interfaced to a data storage and retrieval system. The study showed that (1) both deposition and clearance were highly reproducible in individuals in repeat control studies; (2) acute exposure to 5 ppm sulfur dioxide had no significant effect (P greater than .05) on mucociliary clearance in resting healthy subjects, except perhaps for a small transient change (P = .05) after one hour; (3) pulmonary function tests showed a decrease in maximal midexpiratory flow (P greater than .01), but no other significant changes.

• Research Organization: McMaster Univ. Medical Centre, Hamilton, Ont.
• OSTI ID: 7195025
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 30:11; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BRONCHI
CAMERAS
CHALCOGENIDES
CLEARANCE
COLLOIDS
DATA PROCESSING
DEPOSITION
DISPERSIONS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXCRETION
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
PROCESSING
RADIATION DOSES
RADIOISOTOPES
RESPIRATORY SYSTEM
RETENTION
SOLS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THRESHOLD DOSE
TRACHEA
VERTEBRATES
YEARS LIVING RADIOISOTOPES