Mucociliary clearance of inhaled particles measures at 2 h after ozone exposure in humans

Journal Article · Tue Jun 01 04:00:00 EDT 1993 · Journal of Applied Physiology (1985); (United States)

OSTI ID:6218474

Gerrity, T R; Bennett, W D; Kehrl, H; DeWitt, P J ^[1]

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1. Univ. of North Carolina, Chapel Hill (United States)

Acute exposure of humans to ozone is known to acutely cause pulmonary function decrements, inflammation, and increased permeability of pulmonary epithelium. A single study in humans has also shown that mucociliary transport increases during acute ozone exposure. Because different responses have shown a different time course of recovery after exposure, it was important to examine mucociliary transport at a different time after the cessation of ozone exposure. The authors exposed 15 healthy male and female nonsmoking subjects, on different occasions, to clean air and 0.4 ppm ozone for 1 h while they exercised continuously. Pulmonary function was measured immediately before and after exposure and 90 min and 24 h after exposure. Between 2 and 5 h after each exposure, retention of inhaled 5-[mu]m mass median aerodynamic diameter [sup 99m]Tc-labeled Fe[sub 2]O[sub 3] particles was measured. Each subject returned the next day for a final particle retention measurement. Despite significant changes in pulmonary function, there was no difference in mean whole lung retention time of particles between clean air [77.0 [+-] 0.8 (SE) min] and ozone (78.0 [+-] 0.8 min) exposures, indicating that mucociliary transport is unaffected by ozone exposure when it is measured 2 h after exposure. 25 refs., 4 figs., 2 tabs.

• OSTI ID: 6218474
• Journal Information: Journal of Applied Physiology (1985); (United States), Journal Name: Journal of Applied Physiology (1985); (United States) Vol. 74:6; ISSN JAPHEV; ISSN 8750-7587
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CHALCOGENIDES
CLEARANCE
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON COMPOUNDS
IRON OXIDES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
NUCLEI
ODD-EVEN NUCLEI
OXIDES
OXYGEN COMPOUNDS
OZONE
PARTICLES
RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOI