Case-control studies of bladder cancer and chloraminated drinking water: Feasibility considerations

Conference · · Archives of Environmental Health; (USA)

OSTI ID:5770482

Murphy, P A ^[1]

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1. U.S. Environmental Protection Agency, Cincinnati, OH (USA)

A well-conducted, methodologically sound epidemiologic study is usually the result of careful planning and anticipation by the investigator during the design phase. A thorough assessment of feasibility issues specific to the exposure and disease of interest should also be considered before deciding to proceed with fullscale field work. In general, a feasibility study should assess the following issues: (1) characterization of exposure, (2) identification and measurement of potential confounders and effect modifiers, (3) acquisition of a sufficient sample size to produce precise and useful effect estimates, (4) documentation of the appropriate temporal relationship between exposure and disease, and (5) methods of analysis appropriate for the data to be collected and analyzed. A lack of good information about any one of these five issues should alert the investigator to potential problems. There will be some instances where studies should be either postponed until further information becomes available or abandoned. These feasibility issues are explained within the context of planning for a population-based, case-control study of bladder cancer and consumption of chloraminated drinking water.

• OSTI ID: 5770482
• Report Number(s): CONF-890937--
• Conference Information: Journal Name: Archives of Environmental Health; (USA) Journal Volume: 45:5
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
BLADDER
BODY
CHLORIDES
CHLORINE COMPOUNDS
DISEASES
DRINKING WATER
EPIDEMIOLOGY
HALIDES
HALOGEN COMPOUNDS
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
NEOPLASMS
ORGANS
OXYGEN COMPOUNDS
URINARY TRACT
WATER