In vivo studies of branched chain fatty acids
Studies using (1-C-11)-3-methylheptadecanoic acid (BMHDA) have been performed both in animals and man to define the characteristics of the agent. Evaluation of BMHDA as a myocardial imaging agent in anesthetized dogs revealed blood clearance half times of less than 2 minutes accompanied by prompt myocardial concentration. Within 2 minutes the myocardium could be delineated, Plateau myocardial concentration of 3 to 4% of the injected dose was observed. This value persisted for intervals up to 70 minutes. In addition to the heart, the liver was the only other organ clearly delineated. The prompt concentration of fatty acid in the myocardium and the rapid blood clearance raised the spectre that the fatty acids may behave as Sapirstein tracers in the myocardium - i.e., their distribution may be dominated by regional perfusion and, thereby, make these agents less useful as independent indicators of myocardial metabolism. The effects of severe chronic hypertension of myocardial uptake of BMHDA was studied. These experiments were designed to define whether the myocardium continues to utilize fatty acids as a major substrate when myocardial work is excessive. 7 refs.
- Research Organization:
- Massachusetts Inst. of Tech., Cambridge (USA)
- DOE Contract Number:
- FG02-86ER60460
- OSTI ID:
- 5767405
- Report Number(s):
- DOE/ER/60460-T1; ON: DE88002585
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LIGHT NUCLEI
MAMMALS
MAN
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
SYNTHESIS
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
USES
VASCULAR DISEASES
VERTEBRATES