In vivo studies of branched chain fatty acids
Studies using (1-C-11)-3-methylheptadecanoic acid (BMHDA) have been performed both in animals and man to define the characteristics of the agent. Evaluation of BMHDA as a myocardial imaging agent in anesthetized dogs revealed blood clearance half times of less than 2 minutes accompanied by prompt myocardial concentration. Within 2 minutes the myocardium could be delineated, Plateau myocardial concentration of 3 to 4% of the injected dose was observed. This value persisted for intervals up to 70 minutes. In addition to the heart, the liver was the only other organ clearly delineated. The prompt concentration of fatty acid in the myocardium and the rapid blood clearance raised the spectre that the fatty acids may behave as Sapirstein tracers in the myocardium - i.e., their distribution may be dominated by regional perfusion and, thereby, make these agents less useful as independent indicators of myocardial metabolism. The effects of severe chronic hypertension of myocardial uptake of BMHDA was studied. These experiments were designed to define whether the myocardium continues to utilize fatty acids as a major substrate when myocardial work is excessive. 7 refs.
- Research Organization:
- Massachusetts Inst. of Tech., Cambridge (USA)
- DOE Contract Number:
- FG02-86ER60460
- OSTI ID:
- 5767405
- Report Number(s):
- DOE/ER/60460-T1; ON: DE88002585
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MONOCARBOXYLIC ACIDS
CHEMICAL PREPARATION
DIAGNOSTIC USES
LABELLING
MYOCARDIUM
POSITRON COMPUTED TOMOGRAPHY
CARBON 11
DOGS
HYPERTENSION
IODINE 123
MAN
RATS
THALLIUM 201
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
SYNTHESIS
THALLIUM ISOTOPES
TOMOGRAPHY
USES
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production