Fatty acids and their analogs for myocardial imaging and metabolism
The straight chain radiolabeled fatty acid (FA) show relatively rapid myocardial washout since they could be metabolized by the beta-oxidation and undergo in vivo deiodination. The high levels of free radioiodide in blood requires a special background correction. The use of p-iodo-phenylpentadecanoic acid stabilizes the iodine on the aromatic ring and lowers the amount of free iodide in the blood. This agent was evaluated in many patients, however, translocation of activity from the heart is evident, not as a result of deiodination but as p-Iodo-benzoic acid as a metabolite. To determine whether an analogue designed to inhibit the FA beta-oxidation metabolic process in the myocardium could be a valuable tracer for assessing the myocardial metabolic integrity, we synthesized 1-/sup 14/C-beta-methylheptadecanoic acid (/sup 14/C-BMHDA), a FA analogue. Biodistribution of /sup 14/C-BMHDA was determined in rats (groups of six) in 5 tissues and blood at 5, 15, 30 and 60 minutes and compared to /sup 14/C-palmitic acid (/sup 14/C-PA) a normal FA. A heart concentration of 2.82 and 4.18% I.D./gr at 5 and 60 minutes was observed for /sup 14/C-BMHDA, while /sup 14/C-palmitic acid was 2.65 and 0.89% I.D./gr at 5 and 60 minutes, respectively. 1 ref., 1 tab.
- Research Organization:
- Massachusetts General Hospital, Boston (USA). Physics Research Lab.
- DOE Contract Number:
- FG02-86ER60460
- OSTI ID:
- 5851444
- Report Number(s):
- CONF-8306119-2; ON: DE88002588
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEART
IMAGE PROCESSING
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
MICE
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
RATS
RODENTS
SAMPLE PREPARATION
SCINTISCANNING
SEPARATION PROCESSES
STRUCTURE-ACTIVITY RELATIONSHIPS
THIN-LAYER CHROMATOGRAPHY
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES