Recovery of hematopoietic colony-forming cells in irradiated mice pretreated with interleukin 1 (IL-1)

Technical Report · Fri Jan 01 00:00:00 EST 1988

OSTI ID:5765036

Schwartz, G N; Neta, R; Vigneulle, R M; Patchen, M L; MacVittie, T J

Data in this report determined the effect of a single injection of recombinant interleukin 1 a (rIL-1) prior to irradiation of B6D2F1 mice on the recovery of colony-forming cells (CFC) at early and late times after sublethal and lethal doses of radiation, Injection of rIL-1 promoted an earlier recovery of mature cells in the blood and CFC in the bone marrow and spleen. For example, 8 days after 6.5-Gy irradiation, the number of CFU-E (colony-forming units erythroid), BFU-E (burst-forming units-erythroid), and GMCFC (granulocyte-macrophage colony-forming cells) per femur was approximately 1.5-fold higher in rIL-injected mice than in saline-injected mice. Also, 5, 9, and 12 days after irradiation, the number of both day 8 and day 12 CFU-S (colony-forming units-spleen) was almost twofold greater in bone marrow from rIL1-injected mice. The earlier recovery of CFU-S in rIL-1 injected mice was not associated with an increase in the number of CFU-S that survived immediately after irradiation. Also, 7 months after irradiation, the number of CFU-S per femur of both saline-and rIL-1 injected mice was still < 50% of normal values. Data in this report demonstrate that a single injection of rIL-1 prior to irradiation accelerates early hematopoietic recovery in irradiation mice, but does not prevent expression of radiation-induced front-end damage damage to hematopoietic tissues.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 5765036
• Report Number(s): AD-A-205810/5/XAB; AFRRI-SR-88-46
• Resource Relation: Other Information: Pub. in Experimental Hematology, Vol. 16, 752-757(1988)
• Country of Publication: United States
• Language: English

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560152* - Radiation Effects on Animals- Animals