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Recovery of hematopoietic colony-forming cells in irradiated mice pretreated with interleukin 1 (IL-1)

Technical Report ·
OSTI ID:5765036
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Data in this report determined the effect of a single injection of recombinant interleukin 1 a (rIL-1) prior to irradiation of B6D2F1 mice on the recovery of colony-forming cells (CFC) at early and late times after sublethal and lethal doses of radiation, Injection of rIL-1 promoted an earlier recovery of mature cells in the blood and CFC in the bone marrow and spleen. For example, 8 days after 6.5-Gy irradiation, the number of CFU-E (colony-forming units erythroid), BFU-E (burst-forming units-erythroid), and GMCFC (granulocyte-macrophage colony-forming cells) per femur was approximately 1.5-fold higher in rIL-injected mice than in saline-injected mice. Also, 5, 9, and 12 days after irradiation, the number of both day 8 and day 12 CFU-S (colony-forming units-spleen) was almost twofold greater in bone marrow from rIL1-injected mice. The earlier recovery of CFU-S in rIL-1 injected mice was not associated with an increase in the number of CFU-S that survived immediately after irradiation. Also, 7 months after irradiation, the number of CFU-S per femur of both saline-and rIL-1 injected mice was still < 50% of normal values. Data in this report demonstrate that a single injection of rIL-1 prior to irradiation accelerates early hematopoietic recovery in irradiation mice, but does not prevent expression of radiation-induced front-end damage damage to hematopoietic tissues.
Research Organization:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
OSTI ID:
5765036
Report Number(s):
AD-A-205810/5/XAB; AFRRI-SR-88-46
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BODY
BODY AREAS
BODY FLUIDS
BONE MARROW
DOSES
DRUGS
EVALUATION
HEMATOPOIETIC SYSTEM
IRRADIATION
LEGS
LETHAL DOSES
LETHAL RADIATION DOSE
LIMBS
MAMMALS
MATERIALS
MICE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
SUBLETHAL IRRADIATION
TISSUES
VERTEBRATES