The effect of carbohydrates in milk on the absorption of calcium by postmenopausal women

Journal Article · Mon Apr 01 04:00:00 EST 1991 · Journal of the American College of Nutrition; (USA)

DOI:https://doi.org/10.1080/07315724.1991.10718137· OSTI ID:5760958

Schuette, S A; Yasillo, N J; Thompson, C M ^[1]

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1. Univ. of Chicago, IL (USA)

The purpose of this investigation was to determine if the presence of carbohydrate in milk, either lactose or its hydrolysis products, enhance the bioavailability of calcium (Ca) in milk. Two studies were performed. In study A, fractional Ca absorption was measured in 11 lactose-tolerant postmenopausal women after an oral dose of {sup 47}Ca-equilibrated milk formula containing no carbohydrate (NOCHO), lactose (LACTOSE), or an equivalent amount of glucose plus galactose (SUGAR); all participated in three absorption studies in random order. The NOCHO formula contained 10.0 g protein and 217 mg Ca from a combination of milk mineral and protein isolates; the LACTOSE and SUGAR formulae contained in addition 12 g lactose or 6 g glucose plus 6 g galactose, respectively. In study B, fractional Ca absorption was measured in five postmenopausal women after an oral dose of {sub 47}Ca-equilibrated skim milk (217 mg Ca) and lactase-treated milk, each with sufficient carbohydrate added to equal 12 g. For both studies, the increase in forearm radioactivity 4 and 8 hours after oral {sup 47}Ca administration relative to the increase observed after IV administration was used to estimate fractional Ca absorption. The addition of lactose but not glucose plus galactose to the NOCHO formula enhanced Ca absorption (p less than 0.05). Fractional absorption at 4 hours was 0.386 from the LACTOSE formula compared with 0.310 for both the NOCHO and SUGAR formulae. Those individuals with the lowest absorption in the absence of carbohydrate had the greatest increase with lactose. In contrast, Ca absorption was the same from skim milk as from lactase-treated skim milk (study B).

• OSTI ID: 5760958
• Journal Information: Journal of the American College of Nutrition; (USA), Journal Name: Journal of the American College of Nutrition; (USA) Vol. 10:2; ISSN 0731-5724; ISSN JONUD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ALDEHYDES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL AVAILABILITY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY FLUIDS
CALCIUM
CALCIUM 47
CALCIUM ISOTOPES
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIET
DISACCHARIDES
ELEMENTS
EVEN-ODD NUCLEI
FEMALES
FOOD
GALACTOSE
GLUCOSE
HEXOSES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LACTOSE
MAMMALS
MAN
MATERIALS
MENOPAUSE
METALS
MILK
MONOSACCHARIDES
NUCLEI
OLIGOSACCHARIDES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
PRIMATES
RADIOISOTOPES
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES
WOMEN